DNA Thrombotic Risk Test
$195.00
Are you at increased risk of abnormal blood clots?
The DNA Thrombotic Risk Test can tell you just that.
- Includes variant in F5, F2 and MTHFR genes
- 100% private and confidential online results
- Painless sample collection
- Are you at increased risk of life-threatening blood clots?
DESCRIPTION
Thrombosis is the formation of a blood clot inside a blood vessel, preventing the flow of blood through the circulatory system. Deep vein thrombosis (DVT) is the most common form of venous thrombosis (blood clot). DVT refers to a clot in a deep vein and it often happens in the leg. Symptoms in the affected area include pain, swelling, redness and warmth.
If you suspect a DVT you should contact a doctor as soon as possible, because sometimes the clot may break loose and travel to other parts of the body.
If the clot travels to the lungs, it can block essential blood vessels. This life-threatening complication is known as a pulmonary embolism (PE). Symptoms include a sudden shortness of breath, chest pain, coughing up blood-streaked mucus and a rapid heartbeat.
If the clot travels to the brain, it is also extremely dangerous and can potentially cause a cerebral venous thrombosis. Symptoms include impaired speech, difficulty moving parts of the body, vision problems and severe headaches.
Every year, more people die from a blood-clotting problem than breast cancer and HIV combined. All that is needed is a simple mouth swab to uncover your risk with this DNA test.
THE GENETICS
This thrombotic risk test examines genetic changes in three genes that contribute to an increased risk of thrombosis. The three genes are F5, F2, and MTHFR.
Variants Tested
- F5 – the Factor V Leiden mutation (1691G>A)
- F2 – the prothrombin mutation (20210G>A)
- MTHFR – two mutations (677C>T and 1298A>C)
Since we inherit two copies of each gene – one from each parent – we can have different combinations of these genes. We can inherit two normal copies of a gene (homozygous normal), two copies that carry a genetic mutation (homozygous mutant), or one normal copy and one mutated copy (heterozygous). Each combination of the F5, F2, and MTHFR genes is associated with a different risk of thrombophilia.
Thrombotic Risk by Patient Genotype
| Patient Genotype | Thrombotic Risk |
|---|---|
| heterozygous 1691G>A in the F5 gene | 3-8 times increased risk of thrombosis 2-11 times increased risk of miscarriage |
| homozygous 1691G>A in the F5 gene | 10-80 times increased risk of thrombosis 2-11 times increased risk of miscarriage |
| heterozygous 20210G>A in the F2 gene | 2-5 times increased risk of thrombosis 2-3 times increased risk of miscarriage |
| homozygous 20210G>A in the F2 gene | >5 times increased risk of thrombosis 2-3 times increased risk of miscarriage |
| homozygous 677C>T in the MTHFR gene | Increased risk of thrombosis if folate levels are low |
| 677C>T and 1298A>C mutations in the MTHFR gene | Increased risk of thrombosis if folate levels are low |
REDUCING YOUR RISK OF A BLOOD CLOT
- Maintain a healthy body weight
- Follow a healthy diet
- Increase your blood flow with exercise
- Avoid extended periods of immobility
- Avoid smoking
- Reduce homocysteine levels by getting plenty of folate and other B vitamins
- Wear compression stocking on long flights
- If your risk is very high, seek medical treatment (e.g. anticoagulants)
HOW IT WORKS
Step 1: Order test kit online
Step 2: Collect DNA sample using a painless mouth swab, and mail to the lab in the provided return envelope
Step 3: Receive your results online